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HER2, or human epidermal growth factor receptor 2, is a cancer cell protein which is associated with larger tumours, higher risk of recurrence and poorer clinical outcomes in breast cancer. It is estimated that around patients in England and Wales will now be eligible to receive the drug through routine NHS use. NICE moved to recommend the drug on the basis of clinical data demonstrating that Kadcyla improved progression-free survival compared to trastuzumab alone in patients who saw their tumours shrunk but not eliminated after receiving neoadjuvant therapy with a taxane chemotherapy and HER2-targeted treatment — a population who are at risk of disease re-emergence.
You are viewing BNF. Breast cancer is the most common form of malignancy in women, especially in those aged over 50 years. Established risk factors include age, early onset of menstruation, late menopause, older age at first completed pregnancy, and a family history of breast cancer. The use of oral contraceptives or hormone replacement therapy HRT is also associated with an increased risk of breast cancer. Breast cancer in men is rare. Although risk factors are not fully understood, it may be associated with abnormalities of sex hormone metabolism, including those caused by liver disease or testicular trauma, genetic predisposition, and environmental risk factors such as industrial exposure to chronic heat. Non-invasive breast cancer, also known as ductal carcinoma in situ , is when the cancer remains localised in the ducts. However, in most cases, the cancer is invasive at the time of diagnosis, which means that malignant cells are liable to spread beyond the immediate area of the tumour.
Trastuzumab Herceptin should be used to treat women with early stage HER2 positive breast cancer except where there are concerns about cardiac function, says draft guidance for England and Wales and separate guidance for Scotland published last week. The draft guidance was published by the National Institute for Health and Clinical Excellence NICE , the body that advises on use of treatments by the NHS, only two weeks after the drug was licensed for use in early breast cancer. It recommends the drug as a treatment option for women with early stage HER2 positive breast cancer after surgery, chemotherapy whether neoadjuvant or adjuvant , and radiotherapy if applicable.