This article contains a list of characters from the telenovela Rebelde. Rebelde features several different plotlines, many of which are put on hold for several episodes before they are resumed. Many of the minor characters often play central roles for a single episode before returning to the background.
The guideline makes new recommendations for the choice and number of drugs, as well as the duration of treatment for DR-TB. These recommendations prioritize the use of medications that can be administered orally. The guideline makes clear that treatment should be tailored based on drug-susceptibility testing, and that individuals should not receive medicines to which the Mycobacterium tuberculosis strain is resistant. The guideline includes two other new recommendations. It recommends treatment with a later-generation fluoroquinolone of all infected contacts of multidrug-resistant tuberculosis MDR-TB patients, rather than watchful observation, and it provides evidence-based guidance for the treatment of pregnant women with MDR-TB for the first time. The availability of potent new and repurposed medicines allows practitioners, for the first time, to choose alternatives to injectable drugs, which have long been considered an essential component of treatment regimens for DR-TB. These injectable drugs have well-known toxicities, including irreversible hearing loss. By prioritizing the use of orally administered medicines, the guideline writing committee believes clinicians can spare patients some of the most debilitating effects of TB treatment, make treatment more tolerable and improve outcomes. The guideline committee included specialists in pulmonary medicine, infectious diseases, pediatrics, primary care, public health, epidemiology, economics, pharmacokinetics, microbiology, systematic review methodology and advocacy. This guideline is generally consistent with the World Health Organization's recommendations but includes some different recommendations that are specifically tailored to low-incidence, higher-resource countries of North America and Europe.
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